2019: New York Jets QB Sam Darnold was infamously diagnosed with mono and would miss the following 3 games
2019: Atlanta Braves OF Ronald Acuna became the youngest player ever and the 1st player in franchise history (regardless of age) to put up 35 HR & 35 SB in a single season
2015: Boston Red Sox DH David Ortiz became the only full-time DH to join the exclusive 500-HR club with his 2nd HR of the day. Ortiz finished with 493 of his HR as a DH, which is almost 200 more than the next closest player (Frank Thomas – 296)
1999: 3 years after moving to Baltimore and becoming the Ravens, the Cleveland Browns returned as an expansion team and lost their debut game to the Pittsburgh Steelers
1996: Seattle Mariners SS Alex Rodriguez set an MLB record for the position with his 88th extra-base hit in a victory over the Royals
1988: Arizona Cardinals lost their Phoenix, Arizona debut to the Dallas Cowboys
1976: Seattle Seahawks played their inaugural regular season game, losing to the St. Louis Cardinals
1976: At 50 years old, DH Minnie Minoso returned to the field with the White Sox after a 12-year hiatus, becoming the 4th-oldest player to record a hit and 1 of a handful to play in 4 different decades
1965: San Francisco Giants SP Warren Spahn recorded the 363rd and final victory of his MLB career (most ever by a LHP) with a 2-run complete game against the Cubs